load_params_init: Base-case initial parameter set

In feralaes/cdx2cea: A cost-efectiveness analysis of testing stage II colon cancer patients for the absence of CDX2 biomarker followed by adjuvant chemotherapy

Base-case initial parameter set

Description

load_params_init generates the initial values of the CDX2 CEA model

Usage

load_params_init(
  n_age_init = 65,
  n_age_max = 100,
  n_cycles_year = 12,
  d_c = 0.03,
  d_e = 0.03,
  index_pce = 0.018,
  p_CDX2neg = 0.0717488789237668,
  p_Mets = 0.980840626,
  r_DieMets = 0.03870286,
  r_RecurCDX2pos = 0.003328773,
  hr_RecurCDX2neg = 3.601069078,
  hr_Recurr_CDXneg_Rx = 0.82,
  hr_Recurr_CDXpos_Rx = 1,
  c_Chemo = 1576,
  c_ChemoAdmin = 315,
  c_CRCStg2_init = (32039 - (1391 + 315)),
  c_CRCStg2_cont = 1722,
  c_CRCStg4_cont = 7629,
  ic_DeathCRCStg2 = 41500,
  ic_DeathOCStg2 = 8969,
  c_Test = 112,
  u_Stg2 = 0.74,
  u_Stg2Chemo = 0.67,
  u_Mets = 0.25
)

Arguments

n_age_init	Initial age of the cohort.
n_age_max	Oldest age of the cohort.
n_cycles_year	Number of cycles per year
d_c	Discount factor for costs
d_e	Discount factor for effectiveness
index_pce	Personal consumption expenditures (PCE) price index
p_CDX2neg	Proportion of CDX2-negative patients
p_Mets	Proportion of recurrence being metastatic
r_DieMets	Cancer mortality rate
r_RecurCDX2pos	Rate of recurrence in CDX2 positive patients
hr_RecurCDX2neg	Hazard ratio of recurrence in CDX2 negative vs positive patients
hr_Recurr_CDXneg_Rx	Hazard ratio for disease recurrence among patients with CDX2-negative under chemotherapy versus CDX2-negative patients without chemotherapy.
hr_Recurr_CDXpos_Rx	Hazard ratio for disease recurrence among patients with CDX2-positive under chemotherapy versus CDX2-positive patients without chemotherapy.
c_Chemo	Cost of chemotherapy
c_ChemoAdmin	Cost of chemotherapy administration
c_CRCStg2_init	Initial costs in CRC Stage II (minus chemo and chemotherapy administration)
c_CRCStg2_cont	Continuing costs in CRC Stage II
c_CRCStg4_cont	Continuing costs in CRC Stage IV
ic_DeathCRCStg2	Increase in cost when dying from cancer while in Stage II
ic_DeathOCStg2	Increase in cost when dying from Other Causes (OC) while in Stage II
c_Test	Cost of IHC staining
u_Stg2	Utility for CRC Stage II patients
u_Stg2Chemo	Utility for CRC Stage II patients under chemotherapy
u_Mets	Utility for metastatic recurrence state

Value

List of all parameters

feralaes/cdx2cea documentation built on April 7, 2024, 10:12 a.m.