ftdDNAme: Frontotemporal Dementia (FTD) DNA methylation dataset

In fernandoPalluzzi/SEMdata: Datasets for SEM-based network analysis using the SEMgraph R package

Frontotemporal Dementia (FTD) DNA methylation dataset

Description

DNA methylation (DNAme) profiling by genome tiling array of 105 FTD patients and 150 healthy controls from peripheral blood samples (Li et al., 2014).

Usage

ftdDNAme

Format

ftdDNAme is a list of 2 objects:

1. "pc1", a data matrix of 256 rows (subjects) and 16560 columns (genes) containing the value of the first principal component of DNAme levels, obtained applying a principal component analysis to methylated CpG sites within the promoter region, for each gene (genes with unmethylated CpGs in both conditions were discarded);

2. "group", a binary group vector of 105 FTD patients (1) and 150 healthy controls (0).

Source

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE53740

References

Li Y, Chen JA, Sears RL, Gao F et al. An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy. PLoS Genet 2014 Mar;10(3):e1004211. <https://doi.org/10.1371/journal.pgen.1004211>

Examples

dim(ftdDNAme$pc1)
table(ftdDNAme$group)

fernandoPalluzzi/SEMdata documentation built on June 27, 2022, 7:04 a.m.