Implements the method described in "Network-based analysis of omics data: The LEAN method" [Gwinner Boulday (2016) <DOI:10.1093/bioinformatics/btw676>] Given a protein interaction network and a list of p-values describing a measure of interest (as e.g. differential gene expression) this method computes an enrichment p-value for the protein neighborhood of each gene and compares it to a background distribution of randomly drawn p-values. The resulting scores are corrected for multiple testing and significant hits are returned in tabular format.
Package details |
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Author | Frederik Gwinner |
Maintainer | Frederik Gwinner <frederik.gwinner@gmail.com> |
License | GPL-3 |
Version | 1.4.8 |
Package repository | View on GitHub |
Installation |
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