DR_JonkerSA_Hill2: Bivariate dose-response function under Jonker S/A model

In gilles-guillot/MDR: Test Loewe additivity with Model Deviation Ratio

Description

Compute bivariate dose-response function when each mixture compoent follows a 2-parameter Hill dose-response function and Jonker S/A model holds.

Usage

DR_JonkerSA_Hill2(d1, d2, a1, b1, a2, b2, alpha)

Arguments

d1	dose of first compound: a numeric vector
d2	dose of second compound: a numeric vector
a1	parameter a in Hill-2 DR fuction 1/(1+(a/x)**b) for first compound
b1	parameter b in Hill-2 DR fuction 1/(1+(a/x)**b) for first compound
a2	parameter a in Hill-2 DR fuction 1/(1+(a/x)**b) for second compound
b2	parameter b Hill-2 DR fuction in 1/(1+(a/x)**b) for second compound
alpha	parameter quantifying departure from Loewe additivity in Jonker S/A model

Value

vector of numerical responses

References

Jonker model S/A (Eq. 7 p. 2703 Jonker et al. Env Tox & Chem 24(10) 2005)

gilles-guillot/MDR documentation built on Jan. 21, 2020, 8:09 a.m.