Sim_Mixture: Simulate toxicological/pharmacological mixture experiment...

In gilles-guillot/MDR: Test Loewe additivity with Model Deviation Ratio

Description

Simulate toxicological/pharmacological mixture experiment data

Usage

Sim_Mixture(
  x,
  y,
  n,
  SCDR_model = "Hill2",
  par_Hill,
  interaction_model,
  par_int = NULL,
  distribution,
  par_dist = 1
)

Arguments

x	sequence of doses first compound. May contaon zeroes
y	sequence of doses second compound. May contaon zeroes
n	number of binomial samples at various dose values
SCDR_model	family of the single compound dose-response curve
par_Hill	parameters of the Hill functions. If par_Hill = (a1,b1,a2, b2) a1 is a in 1/(1+(a/x)**b) for first compound b1 is b in 1/(1+(a/x)**b) for first compound a2 is a in 1/(1+(a/x)**b) for second compound b2 is b in 1/(1+(a/x)**b) for second compound
interaction_model	'Loewe','Bliss','Hewlett','Voelund' or 'JonkerSA'
par_int	parameter for interaction model
distribution	distribution of response conditional on Hill function value
par_dist	param of the previous distribution

Value

list with input parameters and simulated responses

gilles-guillot/MDR documentation built on Jan. 21, 2020, 8:09 a.m.