GenerateData: Generate data

In gpaux/Mediana: Clinical Trial Simulations

Description

This function generates data according to the specified data model.

Usage

GenerateData(data.model, sim.parameters)

Arguments

data.model	defines a DataModel object.
sim.parameters	defines a SimParameters object.

Value

This function generates a data stack according to the data model and the simulation parameters objetcs. The object returned by the function is a DataStack object containing:

description	a description of the object.
data.set	a list of size n.sims defined in the sim.parameters object.
data.data.scenario.grid	a data frame indicating all data scenario according to the DataModel object.
data.structure	a list containing the data structure according to the DataModel object.
sim.parameters	a list containing the simulation parameters according to SimParameters object.

References

http://gpaux.github.io/Mediana/

See Also

See Also DataModel and SimParameters.

Examples

## Not run: 
# Generation of a DataStack object
##################################

# Outcome parameter set 1
outcome1.placebo = parameters(mean = 0, sd = 70)
outcome1.treatment = parameters(mean = 40, sd = 70)

# Outcome parameter set 2
outcome2.placebo = parameters(mean = 0, sd = 70)
outcome2.treatment = parameters(mean = 50, sd = 70)

# Data model
case.study1.data.model = DataModel() +
  OutcomeDist(outcome.dist = "NormalDist") +
  SampleSize(c(50, 55, 60, 65, 70)) +
  Sample(id = "Placebo",
         outcome.par = parameters(outcome1.placebo, outcome2.placebo)) +
  Sample(id = "Treatment",
         outcome.par = parameters(outcome1.treatment, outcome2.treatment))


# Simulation Parameters
case.study1.sim.parameters = SimParameters(n.sims = 1000,
                                           proc.load = 2,
                                           seed = 42938001)

# Generate data
case.study1.data.stack = GenerateData(data.model = case.study1.data.model,
                                      sim.parameters = case.study1.sim.parameters)

# Print the data set generated in the 100th simulation run for the 2nd data scenario
case.study1.data.stack$data.set[[100]]$data.scenario[[2]]

## End(Not run)


## Not run: 
#Use of a DataStack object in the CSE function
##############################################

# Outcome parameter set 1
outcome1.placebo = parameters(mean = 0, sd = 70)
outcome1.treatment = parameters(mean = 40, sd = 70)

# Outcome parameter set 2
outcome2.placebo = parameters(mean = 0, sd = 70)
outcome2.treatment = parameters(mean = 50, sd = 70)

# Data model
case.study1.data.model = DataModel() +
  OutcomeDist(outcome.dist = "NormalDist") +
  SampleSize(c(50, 55, 60, 65, 70)) +
  Sample(id = "Placebo",
         outcome.par = parameters(outcome1.placebo, outcome2.placebo)) +
  Sample(id = "Treatment",
         outcome.par = parameters(outcome1.treatment, outcome2.treatment))


# Simulation Parameters
case.study1.sim.parameters = SimParameters(n.sims = 1000,
                                           proc.load = 2,
                                           seed = 42938001)

# Generate data
case.study1.data.stack = GenerateData(data.model = case.study1.data.model,
                                      sim.parameters = case.study1.sim.parameters)

# Analysis model
case.study1.analysis.model = AnalysisModel() +
                             Test(id = "Placebo vs treatment",
                                  samples = samples("Placebo", "Treatment"),
                                  method = "TTest")

# Evaluation model
case.study1.evaluation.model = EvaluationModel() +
                               Criterion(id = "Marginal power",
                                         method = "MarginalPower",
                                         tests = tests("Placebo vs treatment"),
                                         labels = c("Placebo vs treatment"),
                                         par = parameters(alpha = 0.025))

# Simulation Parameters
case.study1.sim.parameters = SimParameters(n.sims = 1000, proc.load = 2, seed = 42938001)

# Perform clinical scenario evaluation
case.study1.results = CSE(case.study1.data.stack,
                          case.study1.analysis.model,
                          case.study1.evaluation.model,
                          case.study1.sim.parameters)

## End(Not run)

gpaux/Mediana documentation built on May 31, 2021, 1:22 a.m.