Description Author(s) See Also
This package allows statistical analysis of genome-wide data with smooth functions using generalized additive models based on the implementation from the R-package 'mgcv'. It provides methods for the statistical analysis of ChIP-Seq data including inference of protein occupancy, and pointwise and region-wise differential analysis. Estimation of dispersion and smoothing parameters is performed by cross-validation. Scaling of generalized additive model fitting to whole chromosomes is achieved by parallelization over overlapping genomic intervals.
Maintainer: Georg Stricker georg.stricker@in.tum.de
Authors:
Alexander Engelhardt alexander.engelhardt@ibe.med.uni-muenchen.de
Julien Gagneur gagneur@in.tum.de
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