Description: The crmSubpathway package is a systematic biological tool to identify cancer-related metabolic subpathways. The main capabilities of this tool are as follows: 1. This function uses the k-clique algorithm to split the metabolic pathways in the KEGG database into metabolic subpathways. 2. A stable metabolic subpathway activity matrix is constructed by GSVA or ssGSEA methods. 3. Cancer-related metabolic subpathways are identified through differential analysis. 4. Visualization
library(devtools)
install_github("hanjunwei-lab/crmSubpathway")
use:library(crmSubpathway)
The crmSubpathway
is published in Frontiers in Oncology. Please cite the following article when using crmSubpathway
:
Xudong Han, Donghua Wang, Qingfei Kong and Junwei Han. Inference of Subpathway Activity Profiles Reveals Metabolism Abnormal Subpathway Regions in Glioblastoma Multiforme. Frontiers in Oncology. https://doi.org/10.3389/fonc.2020.01549.
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