score_delta: Measure p of delta

In hclimente/scudo: Switch Catcher, Uprooting Differentially-expressed Ones

Description

Assigns a probability of an observed difference between conditions as function of the differences observed between the controls.

Usage

score_delta(df, probe, ctrl, delta, minTpm = 0, minSamples = 10)

Arguments

df	data.frame containing the differences.
probe	Unquoted name of the biomarker column (e.g. transcript).
ctrl	Unquoted name of the expression in the control condition column (e.g. tpmCtrl).
delta	Unquoted name of the actual difference between conditions column (e.g. dPSI).
minTpm	Minimum TPM to consider a transcript/gene expressed.
minSamples	Minimum number of samples to consider the differences informative. If the number of samples with a valid value (i.e. >= minTpm) is < minSamples, NAs will be returned.

Value

A copy of df with an extra column p indicating the probability of the difference.

hclimente/scudo documentation built on May 25, 2019, 5:26 p.m.