pk_basic_solution: Two-compartment model solution

In hlweeks/pkpredict: Compartment Model Implementation for Pharmacokinetic Analysis

Two-compartment model solution

Description

Calculates the solution of a two-comparment model.

Usage

pk_basic_solution(k_10, k_12, k_21, v_1, k_R, c_0 = c(0, 0))

Arguments

k_10	Elimination rate from central compartment
k_12	Elimination rate from central to peripheral compartment
k_21	Elimination rate from peripheral to central compartment
v_1	Volume of central compartment
k_R	Rate of infusion (g/h)
c_0	Initial concentrations of c(central, peripheral) compartments

Details

The 'pk_basic_solution' function implements the two-compartment model solution for fixed parameters k_10, k_12, k_21, v_1, k_R, and c_0 (initial concentrations). This function is based on the solution to a nonhomogeneous linear system of ODEs. The basic solution could also be computed using numerical integration, which is commonly used for more complicated models.

Value

List containing concentration in central and peripheral compartments, respectively.

hlweeks/pkpredict documentation built on Oct. 29, 2023, 6:08 a.m.