Description Usage Arguments Value Author(s) References Examples

A function to calculate delta synergy score based on zero interaction potency (ZIP) model

1 2 |

`response.mat` |
a dose-response matrix with concentrations as row names and column names |

`correction` |
a parameter to specify if the baseline correction is used or not. Defaults to TRUE. |

`Emin` |
the minimal effect of the drug used in the 4-parameter log-logistic function to fit the dose-response curve. If it is not NA, it is fixed the value assigned by the user. Defaults to 0. |

`Emax` |
the maximal effect of the drug used in the 4-parameter log-logistic function to fit the dose-response curve. If it is not NA, it is fixed the value assigned by the user. Defaults to 100. |

`nan.handle` |
a parameter to specify if L.4 function or LL.4 function is used when fitting with LL.4 produces NaNs. |

A matrix of delta scores for all the dose pairs for a drug combination. For a does pair with at least one zero concentration, 0 is used as the synergy score.

Liye He liye.he@helsinki.fi, Jing Tang jing.tang@helsinki.fi

Yadav B, Wennerberg K, Aittokallio T, Tang J. Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model. Computational and Structural Biotechnology Journal 2015; 13: 504-513.

1 2 3 | ```
data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
delta.score <- ZIP(data$dose.response.mats[[1]])
``` |

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