hruffieux/echoseq: Replication and simulation of genetic variants, molecular expression levels and other phenotypic data

This package provides functions to emulate molecular quantitative trait locus data and clinical data associated with genetic variants under user-specified association patterns. The data can be the result of pure simulation or can replicate real datasets supplied by the user (which may replace real data when these cannot be shared for diverse privacy reasons). The data generation schemes are based on generally accepted principles of population genetics (Hardy--Weinberg equilibrium, linkage-disequilibrium, natural selection, pleiotropic control, sparsity assumptions). Details in H. Ruffieux, A. C. Davison, J. Hager, I. Irincheeva, Efficient inference for genetic association studies with multiple outcomes, *Biostatistics*, 2017.

Getting started

Package details

LicenseGPL (>= 2) | file LICENSE
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
hruffieux/echoseq documentation built on May 17, 2019, 5:54 p.m.