README.md

In hruffieux/echoseq: Replication and Simulation of Genetic Variants, Molecular Expression Levels and Other Phenotypic Data

echoseq: Faithful replication and simulation of molecular and clinical data

Overview

echoseq is an R package providing functions to emulate molecular quantitative trait locus data, and clinical data associated with genetic variants under user-specified association patterns. The data can be obtained by pure simulation or can replicate real datasets supplied by the user. Datasets simulated using echoseq may replace real datasets when these cannot be shared for diverse privacy reasons. The data generation schemes are based on generally accepted principles of population genetics (Hardy–Weinberg equilibrium, linkage-disequilibrium, natural selection, pleiotropic control, sparsity assumptions, epigenetic control, etc).

Installation

To install, run the following commands in R:

if(!require(remotes)) install.packages("remotes")
remotes::install_github("hruffieux/echoseq")

License and authors

This software uses the GPL v3 license, see LICENSE. Authors and copyright are provided in DESCRIPTION.

Issues

To report an issue, please use the echoseq issue tracker at github.com.

hruffieux/echoseq documentation built on Jan. 10, 2024, 10:06 p.m.