Description Usage Arguments Details Value Author(s) References Examples
It gives the simulation-based p-values of the sum of powered score (SPU) with different power and aSPU test.
1 | approx_aSPU(betas, vcov_mat, pow = c(1:8, Inf), B)
|
betas |
the vector (length = p) of maximum likelihood estimates; p is the number of paramters to be tested. |
vcov_mat |
the p by p variance-covariance matrix of MLE. |
pow |
the power vector for aSPU tests. |
B |
number of simulations |
the suggested power term is c(1:8, Inf)
simulation-based p-values of the sum of powered score (SPU) with different power and aSPU test
Zhiyuan (Jason) Xu, Yiwei Zhang and Wei Pan
Wei Pan, Junghi Kim, Yiwei Zhang, Xiaotong Shen and Peng Wei (2014) A powerful and adaptive association test for rare variants, Genetics, 197(4), 1081-95
Yiwei Zhang, Zhiyuan Xu, Xiaotong Shen, Wei Pan (2014) Testing for association with multiple traits in generalized estimation equations, with application to neuroimaging data. Neuroimage. 96:309-25
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