Description Usage Arguments Author(s) Examples
The parameters alpha and beta are known.
1 | loglikelihood_proportions(theta, x.non, alpha, beta, cvec)
|
theta |
c(p1, p2, ..., pk-1) |
x.non |
vector of non-synonymous mutation count |
cvec |
vector of k positive values c(c1, ..., ck) |
Johanna Bertl
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 | c1 = 0.5; c2 = 10
p1 = 0.2; p2 = 0.8
alpha = 10
beta = 5
mutations = rnegbinmix(n=3000, alpha=alpha, beta=beta, c=c(c1, c2), p = c(p1, p2))
# likelihood surface
p1vec = seq(0.11, 0.3, by=0.01)
llp1 = numeric(20)
for(i in 1:20){
llp1[i] = loglikelihood_proportions(theta=p1vec[i], x.non = mutations, alpha = alpha, beta = beta, cvec=c(c1, c2))
}
plot(p1vec, llp1, t="b")
abline(v=p1, col="red")
|
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