STEAM: STEAM: Significance Threshold Estimation for Admixture...

STEAMR Documentation

STEAM: Significance Threshold Estimation for Admixture Mapping

Description

This package provides two functions for estimating genome-wide significance thresholds for admixture mapping studies using two approaches developed by Grinde, Brown, Reiner, Thornton, and Browning: get_thresh_analytic or get_thresh_statsim. We also provide a function (get_g) which estimates the number of generations since admixture, which is a required input parameter for both significance threshold estimation functions.

STEAM Functions

The function get_thresh_analytic() estimates significance thresholds using an analytic approximation to the family-wise error rate.

The function get_thresh_simstat() estimates significance thresholds by simulating test statistics from their asymptotic distribution.

The function get_g() estimates the number of generations since admixture from the observed pattern of local ancestry correlation.


kegrinde/STEAM documentation built on June 30, 2024, 11:27 p.m.