STEAM | R Documentation |
This package provides two functions for estimating genome-wide significance thresholds for admixture mapping studies using two approaches developed by Grinde, Brown, Reiner, Thornton, and Browning: get_thresh_analytic or get_thresh_statsim. We also provide a function (get_g) which estimates the number of generations since admixture, which is a required input parameter for both significance threshold estimation functions.
The function get_thresh_analytic() estimates significance thresholds using an analytic approximation to the family-wise error rate.
The function get_thresh_simstat() estimates significance thresholds by simulating test statistics from their asymptotic distribution.
The function get_g() estimates the number of generations since admixture from the observed pattern of local ancestry correlation.
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