sim.pheno.bin.GxE: Generates phenotype status

In kwesterman/ESPRESSO.GxE.RV: Power analysis and sample size calculation for a multi-variant gene-environment interaction model

Generates phenotype status

Description

Generates affected and non-affected subjects

Usage

sim.pheno.bin.GxE(
  num.obs = NULL,
  disease.prev = NULL,
  genotype = NULL,
  environment = NULL,
  interaction = NULL,
  subject.effect.data = NULL,
  geno.OR = NULL,
  geno.frac_causal = NULL,
  env.OR = NULL,
  int.OR = NULL
)

Arguments

num.obs	Number of observations to generate per iteration
disease.prev	Prevalence of the binary outcome
genotype	Exposure data for genetic determinant
environment	Exposure data for environment
interaction	data
subject.effect.data	Subject effect data, reflects the heterogenity in baseline disease risk
geno.OR	Odds ratios of the genetic determinant
geno.frac_causal	Fraction of causal genetic variants
env.OR	Odds ratios of the two environments
int.OR	Odds ration of the interaction

Value

A dataframe of phenotype

Author(s)

Gaye A.; Westerman K.

kwesterman/ESPRESSO.GxE.RV documentation built on Aug. 27, 2023, 4:44 a.m.