## need to convert the merged genotypes GRanges to a VRanges
ref <- getSeq(TP53Genome(), mergedGenoP53)
vr <- VRanges(seqnames(mergedGenoP53), ranges(mergedGenoP53),
ref = ref, alt = mergedGenoP53$alt)
mcols(vr) <- mcols(mergedGenoP53)[-1]
geno <- vr
geno$expected.freq <- (geno$freq.ceu.u + geno$freq.yri) / 2L
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