Baselinehazard_IMP: Baselinehazard_IMP In lbeesleyBIOSTAT/MultiCure: EM Algorithms for Fitting Multistate Cure Models

Description

The function Baselinehazard_IMP is used to estimate the baseline hazard functions within the MCEM algorithm under COX baseline hazards

Usage

 ```1 2``` ```Baselinehazard_IMP(datWIDE, CovImp, GImp, YRImp, deltaRImp, beta, alpha, TransCov, ASSUME) ```

Arguments

 `datWIDE` A data frame with the following columns: Y_R, the recurrence event/censoring time delta_R, the recurrence event/censoring indicator Y_D, the death event/censoring time delta_D, the death event/censoring indicator G, the cure status variable. This takes value 1 for known non-cured, 0 for "known" cured and NA for unknown cure status `CovImp` A list with IMPNUM elements containing the imputations of Cov output from MultiCure `GImp` A matrix with IMPNUM elements containing the imputations of G output from MultiCure `YRImp` A matrix with IMPNUM elements containing the imputations of Y_R output from MultiCure `deltaRImp` A matrix with IMPNUM elements containing the imputations of delta_R output from MultiCure `beta` Current estimate of beta `alpha` Current estimate of alpha `TransCov` a list with elements: Trans13, Trans24, Trans14, Trans34, PNonCure. Each list element is a vector containing the names of the variables in Cov to be used in the model for the corresponding transition. 13 is NonCured -> Recurrence, 24 is Cured -> Death, 14 is NonCured -> Death, 34 is Recurrence -> Death. PNonCure contains the names of the covariates for the logistic regression for P(NonCure). `ASSUME` This variables indicates what equality assumptions we are making regarding the 24 and 14 transitions. The possible options are: 'SameHazard': Lambda_14(t) = Lambda_24(t) 'AllSeparate': No restrictions on Lambda_14(t) and Lambda_24(t) 'ProportionalHazard': Lambda_14(t) = Lambda_24(t) exp(Beta0) 'SameBaseHaz': Lambda^0_14(t) = Lambda^0_24(t), No restrictions on beta_14 and beta_24

Value

EST a list containing the estimates for the baseline hazard function (and cumulative baseline hazard function) for the 1->3, 2->4, 1->4, and 3->4 transitions.

lbeesleyBIOSTAT/MultiCure documentation built on April 18, 2018, 11:08 p.m.