STATEOCCUPANCYCOX_IMP: STATEOCCUPANCYCOX_IMP

Description Usage Arguments Examples

View source: R/STATEOCCUPANCYCOX_IMP.R

Description

This function uses RShiny to plot predicted state occupancy probabilities, overall survival probabilities, event-free probabilities, and the transition cumulative hazards for a particular set of covariate values. These probabilities are estimated based on a Multistate cure model fit with COX baseline hazards fit using the MCEM algorithm. The estimated probabilities incorporate only baseline information. This function cannot be applied for prediction when recurrence time is included in the model from recurrence to death.

Usage

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STATEOCCUPANCYCOX_IMP(times, TransCov, newCov, beta, alpha, Basehaz13,
  Basehaz24, Basehaz14, Basehaz34)

Arguments

times

number of iterations for the EM or MCEM algorithm

TransCov

a list with elements: Trans13, Trans24, Trans14, Trans34, PNonCure. Each list element is a vector containing the names of the variables in newCov to be used in the model for the corresponding transition. 13 is NonCured -> Recurrence, 24 is Cured -> Death, 14 is NonCured -> Death, 34 is Recurrence -> Death. PNonCure contains the names of the newCovariates for the logistic regression for P(NonCure).

newCov

A dataframe with columns corresponding to newCovariates used in the model fit. The rows should correspond to the newCovariate values for which we will make our predictions.

beta

Estimate from multistate cure model fit

alpha

Estimate from multistate cure model fit

Basehaz13

Estimate of the baseline hazard for the 1->3 transition. This is estimated using function BaselineHazard_IMP.

Basehaz24

Estimate of the baseline hazard for the 2->4 transition. This is estimated using function BaselineHazard_IMP.

Basehaz14

Estimate of the baseline hazard for the 1->4 transition. This is estimated using function BaselineHazard_IMP.

Basehaz34

Estimate of the baseline hazard for the 3->4 transition. This is estimated using function BaselineHazard_IMP.

shape

Estimate from multistate cure model fit

Examples

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attach(SimulateMultiCure(type = "CovariateMissingness"))
Cov = data.frame(X1,X2)
VARS = names(Cov)
TransCov = list(Trans13 = VARS, Trans24 = VARS, Trans14 = VARS, Trans34 = VARS, PNonCure = VARS)
datWIDE = data.frame( Y_R, Y_D, delta_R , delta_D, G)
fit = MultiCure(iternum = 100, datWIDE, Cov, ASSUME = "SameHazard", TransCov = TransCov, BASELINE = "cox", IMPNUM = 10, COVIMPUTEFUNCTION = COVIMPUTEFUNCTION, COVIMPUTEINITIALIZE = COVIMPUTEINITIALIZE) ### Note: This will take awhile
beta = apply(fit[[3]][,90:100], 1, mean)
alpha =  apply(fit[[4]][,90:100], 1, mean)
haz = Baselinehazard_IMP(datWIDE, CovImp = fit[[5]],GImp = fit[[6]], YRImp = fit[[7]],deltaRImp = fit[[8]], beta, alpha, TransCov, ASSUME = "SameHazard")	
STATEOCCUPANCYCOX_IMP(times = seq(0,100,5), TransCov, newCov = data.frame(X1 = 0, X2 = 0), beta, alpha, Basehaz13 = haz[[1]], Basehaz24 = haz[[2]], Basehaz14 = haz[[3]], Basehaz34 = haz[[4]])  ### Note: This will take awhile

lbeesleyBIOSTAT/MultiCure documentation built on April 18, 2018, 11:08 p.m.