gClinBiomarker is an R package that contains functions to perform baseline and longitutinal biomarker analyses
Two documents are provided: - A user vignette demonstrates how gClinBiomarker package may help in your biomarker analysis - An exapmle use case document which contains more detailed use cases
pdf version of these two documents can be found at inst/doc: https://github.com/lengning/gClinBiomarker/tree/master/inst/doc
The Rmarkdown templates to run the automatic workflows can be found here: https://github.com/lengning/gClinBiomarker-templates
To install this package from R, use
install_github() function from the devtools package
In R, type:
## install.packages("devtools") library(devtools) install_github("lengning/gClinBiomarker")
Use the command
vignette(package = 'gClinBiomarker') to view a list of avaialble vignettes for the
gClinBiomarker package. Then use the command
vignette(<vignett_name>) to view the relevant documentation.
Is your biomarker population your full patient population? Take a look at these functions:
Is your biomarker response a dynamic range? Does it have a skewed distribution? Is it correlated with clinical variables?
Is your biomarker response associated with a clinical outcome? Is it prognostic or predictive? Is there an optimal biomarker cutoff with a consistent trend?
Estimate the clinical benefit within a biomarker subgroup.
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