degCurve: Calculating ratio of proteins turnover using theoretical...

In mengchen18/proturn: System-wise protein turnover curve fitting

Description

Generate ratio of proteins turnover using theoretical formula. This used for control/unit test.

Usage

degCurve(A, B, kd, tcc, t)

synCurve(A, B, kd, tcc, t)

Arguments

A	model parameter A (amplitude), see details
B	model parameter B (offset), see details.
kd	model parameter kd (degradation/synthesis constant), see details.
tcc	model parameter tcc (doubling time), see details.
t	The time points (hours)

Details

Generate withMathJax("$$f(t)=(A-B)\cdot e^-(k_d+\fracln2t_cc)\cdot t+B$$") "The model fitted for the synthesis curve is as:" withMathJax("$$f(t)=(B-A)\cdot e^-(k_s+\fracln2t_cc)\cdot t+A$$") "where t is the time points (given in hours)

Value

A vector of ratios of protein turned over

Examples

 times <- 2^(0:6)
 drat <- degCurve(A = 1, B = 0, kd = 0.05, tcc = Inf, times)
 plot(times, drat)
 times <- 2^(0:6)
 srat <- synCurve(A = 1, B = 0, kd = 0.05, tcc = Inf, times)
 plot(times, srat)

mengchen18/proturn documentation built on May 30, 2019, 4:37 p.m.