structure(list(
absolute_model_path = "/data/home/kylem/src/github/metrumresearchgroup/bbr/inst/model/nonmem/basic/1",
run_details = list(
version = "7.4.4", run_start = NA_real_,
run_end = "Mon Nov 8 11:35:08 EST 2021", estimation_time = 5.28,
covariance_time = 1.29, postprocess_time = 0.46, cpu_time = 6.816,
function_evaluations = 447L, significant_digits = 3.2,
problem_text = "PK model 1 cmt base", mod_file = NA_real_,
estimation_method = "First Order Conditional Estimation with Interaction",
data_set = "../../../../extdata/acop.csv", number_of_subjects = 39L,
number_of_obs = 741L, number_of_data_records = 779L,
output_files_used = c(
"1.lst", "1.cpu", "1.ext", "1.grd",
"1.shk"
)
), run_heuristics = list(
covariance_step_aborted = FALSE,
large_condition_number = FALSE, eigenvalue_issues = FALSE,
correlations_not_ok = FALSE, parameter_near_boundary = FALSE,
hessian_reset = TRUE, has_final_zero_gradient = FALSE,
minimization_terminated = FALSE, eta_pval_significant = FALSE,
prderr = FALSE
), parameters_data = list(list(
method = "TABLE NO. 1: First Order Conditional Estimation with Interaction: Goal Function=MINIMUM VALUE OF OBJECTIVE FUNCTION: Problem=1 Subproblem=0 Superproblem1=0 Iteration1=0 Superproblem2=0 Iteration2=0",
estimates = list(theta = c(
2.31716, 54.6151, 462.514,
-0.0820082, 4.17959
), omega = c(0.0985328, 0, 0.156825), sigma = 1L), std_err = list(theta = c(
0.087208, 3.37551,
30.2623, 0.0561272, 1.37796
), omega = c(
0.0203449, 1e+10,
0.0272401
), sigma = 1e+10), random_effect_sd = list(omega = c(
0.313899,
0, 0.396011
), sigma = 1L), random_effect_sdse = list(
omega = c(0.0324068, 1e+10, 0.0343931), sigma = 1e+10
),
fixed = list(theta = c(0L, 0L, 0L, 0L, 0L), omega = c(
0L,
1L, 0L
), sigma = 1L)
)), parameter_names = list(theta = c(
"THETA1",
"THETA2", "THETA3", "THETA4", "THETA5"
), omega = c(
"OMEGA(1,1)",
"OMEGA(2,1)", "OMEGA(2,2)"
), sigma = "SIGMA(1,1)"), ofv = list(
list(
method = "First Order Conditional Estimation with Interaction",
ofv_no_constant = 2583.311, constant_to_ofv = 1361.86690620932,
ofv_with_constant = 3945.17780715107
)
), condition_number = list(
list(
method = "First Order Conditional Estimation with Interaction",
condition_number = NA_real_
)
), shrinkage_details = list(
list(list(
sub_pop = 1L, eta_bar = c(0.00197362, -0.00620906), ebv_bar_se = c(0.0409479, 0.0612968), pval = c(
0.961558,
0.919316
), eta_sd = c(17.4695, 2.07276), eps_sd = 4.08455,
ebv_sd = c(18.5033, 2.56445), num_subjects = c(
39L,
39L
), eta_vr = c(31.8872, 4.10256), eps_vr = 8.00227,
ebv_vr = c(33.5829, 5.06314)
))
), success = TRUE
), class = c(
"bbi_nonmem_summary",
"bbi_model", "list"
))
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