R/scTHI.R

In miccec/scTHI: Indentification of significantly activated ligand-receptor interactions across clusters of cells from single-cell RNA sequencing data

#' single cell Tumor Hist Interaction (scTHI)
#' 
#' @description  Indentification of  significantly activated ligand-receptor 
#' interactions across clusters of cells from single-cell RNA sequencing data.
#' Single-cell RNA sequencing is the reference technique to characterize the heterogeneity of tumor microenvironment. 
#' The composition of the various cell types making up the microenvironment can significantly affect the way 
#' in which the immune system activates cancer rejection mechanisms. Understanding the cross-talk signals
#'  between immune cells and cancer cells is a fundamental for the identification immuno-oncology therapeutic targets. 
#' scTHI is  a novel method, single cell Tumor-Host Interaction tool (scTHI), 
#' to identify significantly activated ligand-receptor interactions across clusters of cells from 
#' single-cell RNA sequencing data. 
#' cTHI is based on the hypothesis that when patterns of interaction are active, 
#' they are also simultaneously and highly expressed in
#' homogeneous cell populations. We also model the autocrine and paracrine 
#' signalling effects of L-R partners 
#' 
#' @details Please have a look at the vignette for a in-depth introduction to the package.
#' @docType package
#' @name scTHI
NULL