curvep | R Documentation |
The relationship between concentration and response has to be 1 to 1.
The function is the backbone of run_rcurvep()
and combi_run_rcurvep()
.
curvep(
Conc,
Resp,
Mask = NULL,
TRSH = 15,
RNGE = -100,
MXDV = 5,
CARR = 0,
BSFT = 3,
USHP = 4,
TrustHi = FALSE,
StrictImp = TRUE,
DUMV = -999,
TLOG = -24,
...
)
Conc |
Array of concentrations, e.g., in Molar units, can be log-transformed, in which case internal log-transformation is skipped. |
Resp |
Array of responses at corresponding concentrations, e.g., raw measurements or normalized to controls. |
Mask |
array of 1/0 flags indicating invalidated measurements (default = NULL). |
TRSH |
Base(zero-)line threshold (default = 15). |
RNGE |
Target range of responses (default = -100). |
MXDV |
Maximum allowed deviation from monotonicity (default = 5). |
CARR |
Carryover detection threshold (default = 0, analysis skipped if set to 0) |
BSFT |
For baseline shift issue, min.#points to detect baseline shift (default = 3, analysis skipped if set to 0). |
USHP |
For u-shape curves, min.#points to avoid flattening (default = 4, analysis skipped if set to 0). |
TrustHi |
For equal sets of corrections, trusts those retaining measurements at high concentrations (default = FALSE). |
StrictImp |
It prevents extrapolating over concentration-range boundaries; used for POD, ECxx etc (default = TRUE). |
DUMV |
A dummy value, default = -999. |
TLOG |
A scaling factor for calculating the wAUC, default = -24. |
... |
allow other parameters to pass |
A list with corrected concentration-response measurements and several calculated curve metrics.
resp: corrected responses
corr: flags for corrections
ECxx: effective concentration values at various thresholds
Cxx: concentrations for various absolute response levels
Emax: maximum effective concentration, slope of the mid-curve (b/w EC25 and EC75)
wConc: response-weighted concentration
wResp: concentration-weighed response
POD: point-of-departure (first concentration with response >TRSH)
AUC: area-under-curve (in units of log-concentration X response)
wAUC: AUC weighted by concentration range and POD / TLOG (-24)
wAUC_pre: AUC weighted by concentration range and POD
nCorrected: number of points corrected (basically, sum of flags in corr)
Comments: warning and notes about the dose-response curve
Settings: input parameters for this run
PMID:20980217Rcurvep
PMID:27518631Rcurvep
run_rcurvep()
and combi_run_rcurvep()
curvep(Conc = c(-8, -7, -6, -5, -4) , Resp = c(0, -3, -5, -15, -30))
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