moreno-betancur/survtd: Survival analysis with time-dependent covariates

Fit semi-parametric Cox or additive hazards regression models with time- fixed covariates of any type and multiple continuous time-dependent covariates subject to missing data, measurement error or simply observed in discrete time: all these issues are handled with the two-stage Multiple Imputation for Joint Modeling (MIJM) approach developed by Moreno-Betancur et al. (2017). The package also provides easy-to-use implementations of an unadapted version (unMIJM); a simple two-stage approach (simple2S), based on single imputation of the continuous markers from linear mixed models; and the last observation carried forward (LOCF) approach for time-dependent covariates of any type, which is the traditional method to incoporate these in hazard models. Data simulation functions also included.

install.packages("remotes")
remotes::install_github("moreno-betancur/survtd")