BSDE: Calculate the BSDE p-value for a SingleCellExperiment object.

In mqzhanglab/BSDE: Barycenter Single-Cell Differential Expression for Case-Control Studies

Calculate the BSDE p-value for a SingleCellExperiment object.

Description

Calculate the BSDE p-value for a SingleCellExperiment object.

Usage

BSDE(sce, perm_num = 200, unif_round_unit = 0.2, weight = 1, shrink = FALSE)

Arguments

sce	A SingleCellExperiment object. See SingleCellExperiment.
perm_num	The number of permutations for computing Monte Carlo p-value.
unif_round_unit	Bin width for empirical histogram (default: 0.2).
weight	Weight vector (non-negative, length=number of subjects) for subjects. Can be used for inverse probability weighting to control for confounding. Default: 1 for equal weights.
shrink	If TRUE, the range with zero count will be removed to cope with sparsity and speed up the computation. Use TRUE if extremely high expressions are present. Default: FALSE.

Value

a list of p-values

mqzhanglab/BSDE documentation built on March 20, 2022, 5:17 a.m.