The siMEM (si/shRNA Interference Mixed Effects Model) algorithm predicts differential essentiality from pooled phenotypic screens. Such screens typically have multiple reagents (e.g., shRNAs, gRNAs) targeting each gene, and are performed across multiple, genetically heterogeneous, cell lines/samples. The algorithm is detailed in Marcotte et al. 2016 ("The Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities and Resistances."). Pooled screen data formatted for use with the siMEM algorithm can be found at http://neellab.github.io/bfg.
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