tests/testthat/test-ui-ini-lotri.R

In nlmixr2/rxode2: Facilities for Simulating from ODE-Based Models

rxTest({
  test_that("ini will strip covariances and renumber if needed", {
    one.cmt <- function() {
      ini({
        tka <- 0.45
        tcl <- log(c(0, 2.7, 100))
        tv <- 3.45
        eta.ka ~ 0.6
        eta.cl ~ 0.3
        eta.v ~ 0.1
        add.sd <- 0.7
      })
      model({
        ka <- exp(tka + eta.ka)
        cl <- exp(tcl + eta.cl)
        v <- exp(tv + eta.v)
        linCmt() ~ add(add.sd)
      })
    }

    suppressMessages(
      f <- rxode2(one.cmt) %>%
        ini(eta.v + eta.ka + eta.cl ~ c(1,
                                        0.01, 1,
                                        -0.01, 0.01, 1))
    )
    expect_equal(dimnames(f$omega)[[1]],
                 c("eta.v", "eta.ka", "eta.cl"))


    suppressMessages(
      f <- rxode2(one.cmt) %>%
        ini(eta.v + eta.cl ~ c(1,
                               0.01, 1))
    )
    expect_equal(dimnames(f$omega)[[1]],
                 c("eta.ka", "eta.v", "eta.cl"))
  })
})