quartile: quartile method of hit selection
In olobiolo/siscreenr: Analyze Genome-Wide siRNA Screening Campaigns
Description
Usage
Arguments
Details
Value
References
Description
Determine cut-off thresholds for hit selection using the quartile method.
Usage
1
Arguments
x
numeric vector or a data frame
subset
logical vector specifying the subset to be included in the calculation;
cFac
stringency factor c
Details
A less error-prone method of identifying outliers in skewed distributions, see reference for details.
c factor of 1.7239 corresponds to a z score threshold of 3 and an error rate of 0.0027.
c factor of 0.9826 corresponds to a z score threshold of 2 and an error rate of 0.0455.
Value
Named numeric vector of length 2, giving the calculated cut-off thresholds,
given the specified c factor.
References
Robust statistical methods for hit selection in RNA interference high-throughput screening experiments.
Xiaohua Douglas Zhang et al., Pharmacogenetics 2006, Apr 7
doi: 10.2217/14622416.7.3.229
PubMed ID: 16610941
olobiolo/siscreenr documentation built on Nov. 26, 2021, 3:08 p.m.
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Description Usage Arguments Details Value References
Description
Determine cut-off thresholds for hit selection using the quartile method.
Usage
1 |
Arguments
x |
numeric vector or a data frame |
subset |
logical vector specifying the subset to be included in the calculation; |
cFac |
stringency factor c |
Details
A less error-prone method of identifying outliers in skewed distributions, see reference for details.
c factor of 1.7239 corresponds to a z score threshold of 3 and an error rate of 0.0027. c factor of 0.9826 corresponds to a z score threshold of 2 and an error rate of 0.0455.
Value
Named numeric vector of length 2, giving the calculated cut-off thresholds, given the specified c factor.
References
Robust statistical methods for hit selection in RNA interference high-throughput screening experiments.
Xiaohua Douglas Zhang et al., Pharmacogenetics 2006, Apr 7
doi: 10.2217/14622416.7.3.229
PubMed ID: 16610941
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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