create_obj_fn: Creates an MAP objective function

In onwhenrdy/mapstimator: Maximum a posteriori estimator a la NONMEM

Description

Creates an MAP objective function

Usage

create_obj_fn(
  individual_df,
  model,
  event_table,
  inits,
  THETA,
  I_OMEGA,
  SIGMA,
  iCov = NULL,
  error_model = c("proportional", "additive"),
  ...
)

Arguments

individual_df	NONMEM dataframe with individual measurements
model	the RxODE model
event_table	the RxODE event table
inits	a vector of initial values of the state variables (e.g., amounts in each compartment), and the order in this vector must be the same as the state variables (e.g., PK/PD compartments)#'
THETA	Typical values THETA
I_OMEGA	Inverse of model OMEGA as matrix
SIGMA	residual variance SIGMA of the model
iCov	dataframe of individual time-independent covariates or NULL if not used
error_model	The residual error model/function
...	additonal parameters for RxODE 'solve' function

Value

the MAP objective function

onwhenrdy/mapstimator documentation built on July 8, 2020, 10:32 p.m.