map_obj_fn: Objective function of the empicical bayes estimate (EBE)

In onwhenrdy/mapstimator: Maximum a posteriori estimator a la NONMEM

Description

Objective function of the empicical bayes estimate (EBE)

Usage

map_obj_fn(
  ETA,
  I_OMEGA,
  C_i,
  C_m,
  SIGMA,
  error_model = c("proportional", "additive")
)

Arguments

ETA	ETAs of PK/PD-Parameter of the individual as row vector
I_OMEGA	Inverve of the IIV of the PK-Parameter (interindividual variance)
C_i	observed values of the individual
C_m	simulated values for the individual
SIGMA	Residual variance of the model
error_model	The residual error model/function

Value

Objective function value

onwhenrdy/mapstimator documentation built on July 8, 2020, 10:32 p.m.