Shedden2008 | R Documentation |
Retrospective data was collected across multiple sites for 442 patients with adenocarcinoma of the lung including their survival times, some additional clinical and demographic data, and expression levels of 22,283 genes taken from the tumor sample.
S
: A two-column matrix containing the survival data. First
column is time on study (in months), second column is the failure
indication (1=died)
X
: Gene expression measurements
Z
: Clinical covariates, which include Sex
,
Age
, Race
, AdjChemo
(whether the patient
received adjuvant chemotherapy), SmHist
(smoking history),
Margin
, and Grade
n = 442
p = 22,283
The object fData
contains the associated gene names and gene
symbols for the (mapped) probes in X
. Rows of fData
correspond to columns of X
, and are named accordingly.
Shedden K, Taylor JMG, Enkemann SA, Tsao M-S, Yeatman TJ, Gerald WL, Eschrich S, Jurisica I, Giordano TJ, Misek DE, Chang AC, Zhu CQ, Strumpf D, Hanash S, Shepherd FA, Ding K, Seymour L, Naoki K, Pennell N, Weir B, Verhaak R, Ladd-Acosta C, Golub T, Gruidl M, Sharma A, Szoke J, Zakowski M, Rusch V, Kris M, Viale A, Motoi N, Travis W, Conley B, Seshan VE, Meyerson M, Kuick R, Dobbin KK, Lively T, Jacobson JW and Beer DG (2008). Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nature Medicine, 14: 822-827.
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