glcamd: Genetic association study of glaucoma and macular...
In pbreheny/hdrm: High-Dimensional Regression Modeling
glcamd R Documentation
Genetic association study of glaucoma and macular degeneration
Description
This data set comes from a study carried out at the University of Iowa
investigating the genetic causes of primary open-angle glaucoma (GLC) and
age-related macular degeneration (AMD). In the study, 400 AMD patients and 400
GLC patients were recruited, and their genotype determined at roughly 500,000
genetic loci. The idea here is that each group could serve as the control group
group for the other disease.
This is a subset of the data; it does not consider all 500,000 genetic loci, but
rather a subset of 497 SNPs from 30 genes that have been previously suggested
may play a role in AMD.
Format
-
y: Disease status: either 'glc' or 'amd'
-
x: A matrix with 800 rows and 699 columns of SNP genotypes (0/1/2)
-
group: For each SNP, this is the nearest gene. There are 30 genes
altogether.
Source
Scheetz TE, Fingert JH, Wang K, Kuehn MH, Knudtson KL, Alward WLM, Boldt HC,
Russell SR, Folk JC, Casavant TL Braun TA, Clark AF, Stone EM, and Sheffield
VC (2013). A Genome-Wide Association Study for Primary Open Angle Glaucoma and
Macular Degeneration Reveals Novel Loci. PLOS ONE 8:
e58657. https://doi.org/10.1371/journal.pone.0058657
pbreheny/hdrm documentation built on July 4, 2025, 12:04 p.m.
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| glcamd | R Documentation |
Genetic association study of glaucoma and macular degeneration
Description
This data set comes from a study carried out at the University of Iowa investigating the genetic causes of primary open-angle glaucoma (GLC) and age-related macular degeneration (AMD). In the study, 400 AMD patients and 400 GLC patients were recruited, and their genotype determined at roughly 500,000 genetic loci. The idea here is that each group could serve as the control group group for the other disease.
This is a subset of the data; it does not consider all 500,000 genetic loci, but rather a subset of 497 SNPs from 30 genes that have been previously suggested may play a role in AMD.
Format
-
y: Disease status: either'glc'or'amd' -
x: A matrix with 800 rows and 699 columns of SNP genotypes (0/1/2) -
group: For each SNP, this is the nearest gene. There are 30 genes altogether.
Source
Scheetz TE, Fingert JH, Wang K, Kuehn MH, Knudtson KL, Alward WLM, Boldt HC, Russell SR, Folk JC, Casavant TL Braun TA, Clark AF, Stone EM, and Sheffield VC (2013). A Genome-Wide Association Study for Primary Open Angle Glaucoma and Macular Degeneration Reveals Novel Loci. PLOS ONE 8: e58657. https://doi.org/10.1371/journal.pone.0058657
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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