glcamd: Genetic association study of glaucoma and macular...

glcamdR Documentation

Genetic association study of glaucoma and macular degeneration

Description

This data set comes from a study carried out at the University of Iowa investigating the genetic causes of primary open-angle glaucoma (GLC) and age-related macular degeneration (AMD). In the study, 400 AMD patients and 400 GLC patients were recruited, and their genotype determined at roughly 500,000 genetic loci. The idea here is that each group could serve as the control group group for the other disease.

This is a subset of the data; it does not consider all 500,000 genetic loci, but rather a subset of 497 SNPs from 30 genes that have been previously suggested may play a role in AMD.

Format

  • y: Disease status: either 'glc' or 'amd'

  • x: A matrix with 800 rows and 699 columns of SNP genotypes (0/1/2)

  • group: For each SNP, this is the nearest gene. There are 30 genes altogether.

Source

Scheetz TE, Fingert JH, Wang K, Kuehn MH, Knudtson KL, Alward WLM, Boldt HC, Russell SR, Folk JC, Casavant TL Braun TA, Clark AF, Stone EM, and Sheffield VC (2013). A Genome-Wide Association Study for Primary Open Angle Glaucoma and Macular Degeneration Reveals Novel Loci. PLOS ONE 8: e58657. https://doi.org/10.1371/journal.pone.0058657


pbreheny/hdrm documentation built on July 4, 2025, 12:04 p.m.