Scoring method of Biological Networks based on NPA (Network Perturbation Amplitude) algorithm. The methodology implemented enables to translate the gene expression fold-changes into differential values for each network node, and to summarize this at the network level to provide a quantitative assessment of the degree of perturbation of the network model, the Network Perturbation Amplitude (NPA). Combining multiple relevant network models, the overall biological impact (BIF) of a perturbing agent, the Biological Impact Factor, can be calculated by aggregating individual NPA scores.
|Author||Florian Martin <Florian.Martin@pmi.com>, Sylvain Gubian <Sylvain.Gubian@pmi.com>|
|Bioconductor views||DifferentialExpression GeneExpression GraphAndNetwork MathematicalBiology Network SystemsBiology Transcriptomics Visualization|
|Maintainer||Sylvain Gubian <DL.RSupport@pmi.com>|
|Package repository||View on GitHub|
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