pmpsa-hpc/NPA: Network Perturbation Amplitude

Scoring method of Biological Networks based on NPA (Network Perturbation Amplitude) algorithm. The methodology implemented enables to translate the gene expression fold-changes into differential values for each network node, and to summarize this at the network level to provide a quantitative assessment of the degree of perturbation of the network model, the Network Perturbation Amplitude (NPA). Combining multiple relevant network models, the overall biological impact (BIF) of a perturbing agent, the Biological Impact Factor, can be calculated by aggregating individual NPA scores.

Getting started

Package details

AuthorFlorian Martin <[email protected]>, Sylvain Gubian <[email protected]>
Bioconductor views DifferentialExpression GeneExpression GraphAndNetwork MathematicalBiology Network SystemsBiology Transcriptomics Visualization
MaintainerSylvain Gubian <[email protected]>
Licensefile LICENSE
Version0.99.0
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
install.packages("remotes")
remotes::install_github("pmpsa-hpc/NPA")
pmpsa-hpc/NPA documentation built on Dec. 19, 2018, 10:01 a.m.