transform_micro: Transform Micro Parameters

In qPharmetra/qpToolkit: qPharmetra R Tools

Transform Micro Parameters

Description

Transforms PK micro parameters into compartmental parameters. Designed as a table-friendly wrapper for micro2macro. Tries to calculate AUC = dose/CL, VSS = V1+V2+V3, and Vz = CL/gamma.

Usage

transform_micro(x, FUN, digits = 3, ...)

Arguments

x	data.frame with V1, k10, and optionally k12, k21, k13, k31
FUN	a list-based function to transform micro parameters, e.g., pmxTools::calc_derived()
digits	places of significance for numerics, or NULL for raw results
...	passed to FUN

Value

data.frame

Examples

set.seed(0)
x = data.frame(
 dose = 10,
 V1 = sample(4:10, size = 3, replace = TRUE),
 k10 = exp(rnorm(3, mean=log(0.79), sd=log(2))),
 k12 = exp(rnorm(3, mean=log(0.95), sd=log(2))),
 k13 = exp(rnorm(3, mean=log(0.005), sd=log(2))),
 k21 = exp(rnorm(3, mean=log(1.24), sd=log(2))),
 k31 = exp(rnorm(3, mean=log(0.036), sd=log(2)))
)

library(pmxTools)
library(magrittr)
# 3 CMT
x %>%  transform_micro( calc_derived )
# 2 CMT
x %>% dplyr::select(-k13) %>% transform_micro( calc_derived )
# 1 CMT
x %>% dplyr::select(-k13, -k12) %>% transform_micro( calc_derived )

qPharmetra/qpToolkit documentation built on May 24, 2023, 8:52 a.m.