mr.raps: Recommended 'mr.raps' procedure

In qingyuanzhao/mr.raps: Two Sample Mendelian Randomization using Robust Adjusted Profile Score

Recommended mr.raps procedure

Description

Recommended mr.raps procedure

Usage

mr.raps(
  data,
  diagnostics = TRUE,
  over.dispersion = TRUE,
  loss.function = "huber",
  ...
)

Arguments

data	A data frame (see Details)
diagnostics	Logical indicator for showing diagnostic plots.
over.dispersion	Should the model consider overdispersion (systematic pleiotropy)? Default is FALSE.
loss.function	Either the squared error loss (l2) or robust loss functions/scores (huber or tukey).
...	Additional parameters to be passed to mr.raps.shrinkage (default is shrinkage=FALSE).

Details

This function calls mr.raps.shrinkage with overdispersion = TRUE, loss.function = "huber". The input data frame should contain the following variables:

1. beta.exposure

2. beta.outcome

3. se.exposure

4. se.outcome

See Also

mr.raps.shrinkage

Examples

# Example 1
mr.raps(bmi.sbp)

# Example 2
data(lipid.cad)
data <- subset(lipid.cad, lipid == "hdl" & restrict &
gwas.selection == "teslovich_2010" &
gwas.outcome == "cardiogramplusc4d_1000genome")
mr.raps(data)

qingyuanzhao/mr.raps documentation built on June 13, 2025, 12:38 p.m.