DVR_ref_Logan: Non-invasive reference Logan method
In ropensci/tacmagic: Positron Emission Tomography Time-Activity Curve Analysis

Description Usage Arguments Value References See Also Examples

This calculates the coefficient from the non-invasive Logan method, which is equal to DVR. Works for a single tac (target).

1 2	DVR_ref_Logan(tac_data, target, ref, k2prime, t_star, error = 0.1, method = "trapz")

`tac_data`	The time-activity curve data from tac_roi()
`target`	The name of the target ROI, e.g. "frontal"
`ref`	The reference region, e.g. "cerebellum"
`k2prime`	A fixed value for k2' must be specified (e.g. 0.2)
`t_star`	If 0, t* will be calculated using find_t_star()
`error`	For find_t_star()
`method`	Method of integration, "trapz" or "integrate"

Data frame with calculate DVRs for all ROIs

Logan, J., Fowler, J. S., Volkow, N. D., Wang, G.-J., Ding, Y.-S., & Alexoff, D. L. (1996). Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data. Journal of Cerebral Blood Flow & Metabolism, 16(5), 834-840. https://doi.org/10.1097/00004647-199609000-00008

Other Logan plot functions: DVR_all_ref_Logan, dvr, plot.ref_Logan

f <- system.file("extdata", "AD06.tac", package="tacmagic")
fv <- system.file("extdata", "AD06_TAC.voistat", package="tacmagic")
AD06_tac <- load_tac(f, format="PMOD")
AD06_volume <- load_vol(fv, format="voistat")
AD06 <- tac_roi(tac=AD06_tac, volumes=AD06_volume, ROI_def=roi_ham_pib(),  
                merge=FALSE, PVC=FALSE)                             
               
AD06_DVR_fr <- DVR_ref_Logan(AD06, target="frontal", ref="cerebellum",
                             k2prime=0.2, t_star=0)