scoringFun: Scoring ligand-receptor interactions

In saschajung/Intercom: Reconstruction of Functional Cell-Cell Communication Networks

Scoring ligand-receptor interactions

Description

Calculates the probability of interaction for each potential ligand-receptor association.

Usage

scoringFun(
  data,
  tissue.R.TF,
  tissue.LR,
  LR,
  sig.cutoff = 0.9,
  z.score.cutoff = 0
)

Arguments

data	A data frame of gene expression values
tissue.R.TF	Data frame of significant receptor-TF associations.
tissue.LR	Data frame of potential ligand-receptor interactions
LR	Data frame of ALL ligand-receptor interactions
sig.cutoff	Significance cutoff as a percentile (ranges from 0 (most permissive) to 1 (most strict)) (default: 0.9)
z.score.cutoff	An optional z-score cutoff from bootstrapping (DEPRECATED; DO NOT CHANGE)

Value

Data frame significant ligand-receptor interactions

saschajung/Intercom documentation built on May 27, 2023, 5:11 p.m.