Constructor for a Study
1 2 |
alpha |
Significance level [0,1] (see also two-sided indicator) |
power |
Power [0,1] |
HR |
Hazard ratio to be detected |
r |
Control:Experimental subject balance (1:r), i.e. nE/nC=r. r=1 corresponds to equally many subjects in both arms. 2 means we have twice the number of subjects in the experimental arm. |
N |
Number of subjects to be recruit (integer) |
study.duration |
Number of months the study will be going. |
ctrl.median |
Median time to an event in the control group. |
k |
non-uniformity of accrual (integer, 1=uniform). Non-uniform accrual is allowed for using the following distribution for the probability of a patient entering the trial at time b within the accrual period [0,B]: F(b)=b_k/B_k; f(b)=k b_{k-1}/B_k where k is the measure of non-uniformity (k>0). k=1 indicates uniform accrual. This implies that during the first half of the accrual period, 1/2^k of the patients will be recruited. Half of the patients will be recruited by time B/2^{1/k}. |
acc.period |
Accrual time. |
two.sided |
If TRUE, two sided test will be used (i.e. alpha/2). |
shape |
The Weibull shape parameter |
dropout |
if subjects drop out in study (due to competing risks not as there is a finite follow up time)
then this argument should contain a list with proportion and time and optionally shape i.e.
|
lag.settings |
The |
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