get_onsetHazard: Calculate the onset hazard for an individual

In simrvprojects/SimRVPedigree: Simulate Pedigrees Ascertained for a Rare Disease

Description

Calculate the onset hazard rate of disease for an individual given the carrier probability and the genetic relative risk for the subtype and the individual's RV status.

Usage

get_onsetHazard(sub_hazard, sub_GRR, carrier_prob, RV_status)

Arguments

sub_hazard	The hazard rate of disease for the subtype of interest
sub_GRR	The genetic relative risk of disease for the subtype of interest.
carrier_prob	Numeric. The carrier probability for all causal variants with relative-risk of disease GRR. By default, carrier_prob = 0.002
RV_status	Numeric. RV_status = TRUE if the individual is a carrier of a rare variant that increases disease suseptibility, and FALSE otherwise.

Value

The baseline age-specific hazard rates of disease

simrvprojects/SimRVPedigree documentation built on Feb. 12, 2020, 6:12 p.m.