View source: R/calculate_MDE_continuous_variable.R
calculate_MDE_biomarker | R Documentation |
Calculate the minimal detectable effect (Hazard Ratio) given an observed number of events for a continuous variable (based on Schoenfeld's formula) Reference: "Sample-Size Calculations for the Cox Proportional Hazards Regression Model with Nonbinary Covariates" by F.Y. Hsieh, PhD, and Philip W. Lavori, PhD (2000)
calculate_MDE_biomarker(number_of_events, alpha = 0.05, sd = 1)
number_of_events |
Number of events |
alpha |
1-sided alpha (Type I error) |
sd |
Standarad deviation of the continuous covariate (default is 1 assuming the continuous marker is standardized) |
Minimal detectable effect
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