concept_spatial_trajectory | R Documentation |
Spatial Gradient Screening conceptualizes changes in gene expression or, generally speaking, changes in expression of numeric features as a continuum in two dimensional space. It uses spatial annotations or spatial trajectories as references that are indicative of biological forces to analyse gene expression changes dependent on the distance to these forces.
Please refer to Kueckelhaus J., Frerichs S. et al., 2024 for a detailed explanation.
A spatial trajectory is a linear segment with a start and an end point which indicates a 'direction'. It can be used within the framework of Spatial Gradient Screening (SGS) as a spatial reference to abstract biological forces such as tumorous growth, increasing cellular density or proximity to a border.
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