knitr::opts_chunk$set( collapse = TRUE, comment = "#>", fig.path = "man/figures/README-", out.width = "75%" )
Overall, ‘idpr’ aims to integrate tools for the computational analysis of intrinsically disordered proteins within R. This package is used to identify known characteristics of IDPs within a sequence of interest with easily reported and dynamic results. Additionally, this package also includes tools for IDP-based sequence analysis to be used in conjunction with other R packages. See our recently published peer-reviewed publication in PLOS ONE (https://doi.org/10.1371/journal.pone.0266929)
Please Refer to idpr-vignette.Rmd file for a detailed introduction to the idpr package.
Links to the vignettes found at the Bioconductor landing page (here) or
You can install the stable release version version from Bioconductor with:
if (!requireNamespace("BiocManager", quietly = TRUE)) install.packages("BiocManager") BiocManager::install("idpr")
Additionally, you can install the development version from Bioconductor with:
if (!requireNamespace("BiocManager", quietly = TRUE)) install.packages("BiocManager") # The following initializes usage of Bioc devel BiocManager::install(version='devel')
Or you can install the most recent development version from GitHub with:
# install.packages("devtools") #if not already installed devtools::install_github("wmm27/idpr")
This is a basic example to quickly profile your protein of interest:
library(idpr) P53_HUMAN <- TP53Sequences[2] #Getting a pre-loaded sequence from idpr print(P53_HUMAN) P53_ID <- "P04637" #Human TP53 UniProt ID #Generates the IDP Profile: idprofile(sequence = P53_HUMAN, uniprotAccession = P53_ID, proteinName = "TP53 Human", #Optional Argument window = 11, #Optional Argument pKaSet = "Lehninger", #Optional Argument iupredType = "redox" #Optional Argument )
Please Refer to idpr-vignette.Rmd file for a detailed introduction to the idpr package. Link to the Vignette (here)
For use and details on 'idpr', see our peer-reviewed article published in PLOS ONE (https://doi.org/10.1371/journal.pone.0266929)
citation("idpr")
Sys.time() Sys.Date() R.version
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