lfsChompret2015: The Chompret criteria for Li-Fraumeni syndrome

In wwylab/LFSPRO: TP53 germline mutation carrier estimation and cancer risk predictions

The Chompret criteria for Li-Fraumeni syndrome

Description

Use the updated Chompret criteria 2015 version to identify TP53 germline mutation carriers in the family.

Usage

lfsChompret2015(fam.data, cancer.data, counselee.id)

Arguments

fam.data	Family information data. See fam.data for details.
cancer.data	Cancer information data. See cancer.data for details.
counselee.id	Data frame including two variables: fam.id (family id of counselees) and id (individual id of counselees).

Value

A data frame of three columns:fam.id, id and result. The result column is a vector of TRUE/FALSE for all counselees indicating whether they are predicted to be TP53 mutation carriers. TRUE: carrier. FALSE: non-carrier.

Author(s)

Gang Peng

References

Chompret, A., et al. (2001). Sensitivity and predictive value of criteria for p53 germline mutation screening. J Med Genet, 38(1): 43-47.

Tinat, J., et al. (2009). 2009 version of the Chompret criteria for Li Fraumeni syndrome. J Clin Oncol, 27(26): e108-109.

Bougeard, G., et al.(2015). Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers. J Clin Oncol, 33(21): p. 2345-52.

See Also

lfsClassic, lfspro, lfsChompret2009

Examples

options(stringsAsFactors = FALSE)
fam.id <- c("fam1","fam2","fam2","fam2","fam2")
id <- c(0,0,2,100,200)
counselee.id <- data.frame(fam.id, id)
lfsChompret2015(fam.data, cancer.data, counselee.id)

wwylab/LFSPRO documentation built on Feb. 1, 2023, 1:05 a.m.