lkNoneAffect: Likelihood for un-affected individuals

In wwylab/LFSPRO: TP53 germline mutation carrier estimation and cancer risk predictions

Likelihood for un-affected individuals

Description

The probability of observing cancer outcome given genotype for each un-affected individual in the family.

Usage

lkNoneAffect(penetrance, age)

Arguments

penetrance	List. Two component of list indicates the penetrance of male and female (fMX: male, fFX: female). For each component, it is a 110*3 matrix containing the penetrance from age 1 to age 110 for three kinds of genotype: P530 (wild type), P531 (one allele mutation) and P532 (two alleles mutation). See lfspenet.2010 for details.
age	The age when the individual is still healthy.

Value

The likelihood (Pr(D|G)) for the un-affected individual at 'age' years old. G, genotype, can be TP530 (wild type), TP531 (one allele of TP53 mutated) and PT532 (both alleles of TP53 mutated).

Author(s)

Gang Peng

See Also

calLK

Examples

lkNoneAffect(lfspenet.2010$fFX, 50)

wwylab/LFSPRO documentation built on Feb. 1, 2023, 1:05 a.m.