lfsClassic: The Classic criteria for Li-Fraumeni syndrome

In wwylab/LFSPRO: TP53 germline mutation carrier estimation and cancer risk predictions

The Classic criteria for Li-Fraumeni syndrome

Description

Use the Classic criteria to identify TP53 germline mutation carriers in the family.

Usage

lfsClassic(fam.data, cancer.data, counselee.id)

Arguments

fam.data	Family information data. See fam.data for details.
cancer.data	Cancer information data. See cancer.data for details.
counselee.id	Data frame including two variables: fam.id (family id of counselees) and id (individual id of counselees).

Value

A data frame of three columns:fam.id, id and result. The result column is a vector of TRUE/FALSE. for all counselees indicating whether they are predicted to be TP53 mutation carriers. TRUE: carrier. FALSE: non-carrier.

Author(s)

Gang Peng

References

Li, F. P., et al. (1988). A cancer family syndrome in twenty-four kindreds. Cancer Res, 48(18): 5358-5362.

See Also

lfsChompret2015, lfspro

Examples

options(stringsAsFactors = FALSE)
fam.id <- c("fam1","fam2","fam2","fam2","fam2")
id <- c(0,0,2,100,200)
counselee.id <- data.frame(fam.id, id)
lfsClassic(fam.data, cancer.data, counselee.id)

wwylab/LFSPRO documentation built on Feb. 1, 2023, 1:05 a.m.