taurefList: Lookup Table for Computing Tau Scores

In yduan004/signatureSearch_data: Datasets for signatureSearch package

Lookup Table for Computing Tau Scores

Description

This dataset is generated by searching all signatures in the LINCS database against itself to obtain a background distribution of NCS values (Qref). The latter is used to compute the Tau scores of the gess_lincs method in the signatureSearch package. The Tau score compares the observed enrichment score to all others in Qref. It represents the percentage of reference queries with a lower |NCS| than |NCSq,r|, adjusted to retain the sign of NCSq,r. NCSq,r is the normalized connectivity score for signature r relative to query q. A tau of 90 indicates that only 10 percent of reference perturbations showed stronger connectivity to the query.

References

For a detailed description of the gess_lincs method and its scores, please refer to the vignette of the signatureSearch package by running browseVignettes("signatureSearch").

Subramanian, A., Narayan, R., Corsello, S. M., Peck, D. D., Natoli, T. E., Lu, X., Golub, T. R. (2017). A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. Cell, 171(6), 1437-1452.e17. https://doi.org/10.1016/j.cell.2017.10.049

See Also

gess_lincs

Examples

library(ExperimentHub)
eh <- ExperimentHub()
taurefList <- eh["EH3233"]
# taurefList <- eh[["EH3233"]]

yduan004/signatureSearch_data documentation built on April 7, 2023, 5:02 a.m.