MPA.simul: Simulate copy number data for a case-control study.

In MPAlars: lars algorithm

Description

Simulate copy number data for a case-control study.

Usage

  MPA.simul(n, nbSNP, probCas, nbSeg, meanSegmentSize,
    prob, alpha = 15)

Arguments

n	Number of individuals.
nbSNP	Size of the DNA sequence.
probCas	Probability to be a case individual.
nbSeg	Number of causal segments.
meanSegmentSize	The mean size of anormal segment.
prob	A 2*2 matrix containing probabilities: prob[1,1]=probability to have an anomaly to a SNP given the person does not have the disease and the SNP is causal. prob[1,2]=probability to have an anomaly to a SNP given the person does not have the disease and the SNP is not causal. prob[2,1]=probability to have an anomaly to a SNP given the person has the disease and the SNP is causal. prob[2,2]=probability to have an anomaly to a SNP given the person has the disease and the SNP is not causal.
alpha	Parameter of the beta(alpha,alpha).

Value

a list containing:

data	A matrix of size n*nbSeg, containing values of the copy-number signal.
response	A vector of size n containing the cas/control status.
causalSNP	A vector of size nbSeg containing the center of causal segments.

Author(s)

Quentin Grimonprez, Serge Iovleff

Examples

MPA.simul(50,10000,0.4,10,150,matrix(c(0.1,0.8,0.001,0.001),nrow=2))

MPAlars documentation built on May 2, 2019, 5:47 p.m.